Sant’Andrea Church is located in the historical center of Spello.The first written document regarding this church dates 1025, when is mentioned as a property of Camaldolese monks of Mount Subasio, The structure of the church is a Latin cross and it has a single nave. There are 3 major artistic treasures : one is the is a large panel of Pinturicchio, second is the crucifix by a follower of Giotto, and third a paint by Dono Doni.